AGE-M

AGE-M

Commercial Name

AGE®-M

Generic Name

Vitamin A, C & E

Composition

Each film coated tablet contains Beta carotene USP 6mg, Vitamin-C BP 200mg and Vitamin E USP 50mg.

Description

Age®-M is a film coated tablet. It is a unique combination of three antioxidant vitamins namely Beta carotene (Pro Vitamin-A), Ascorbic Acid (Vitamin-C) and dl-alpha Tocopheryl Acetate (Vitamin-E).

Indication

Antioxidant vitamins Beta Carotene, Vitamin-C and Vitamin-E present in AGE-M tablet have been linked with reduced risks of cardiovascular diseases in human. All of these three antioxidant vitamins have an important role in brain ageing process and have implications for prevention of progressive cognitive impairment in elderly human. These antioxidant Vitamins have also been linked with reduced risk of Cataract. Supplementation of Beta-Carotene and Vitamin-E may reduce bile acid-induced DNA damage and has a protective role against the DNA damaging capacity of secondary bile acids lithocholate, deoxycholate and Vitamin-C, Vitamin-E can protect oxidatively induced DNA damage. Supplementation with Vitamin-E shows to reduce the susceptibility of blood lipoproteins (the potect that carry cholesterol in the blood) to oxidation, which is the major causative factor in the formation of artheromata in the walls of blood vessels. Vitamin-E also protects the immune system and hence helps to combat infection and chronic diseases. Vitamin-E may also be of value in reversing the age-related trend towards decreased competence of the immune systems as well as other age-related degenerative changes. Moreover, it was recently reported that high dose supplementation with Vitamin-C could correct the elevated sorbitol level seen in diabetics. Inhibiting the activity of the enzyme aldose reductase. Vitamin-C is the most powerful reducing agent known to be present in living tissues. It is a co-factor in numerous biological processes. Vitamin-C plays an important part in the response of body to stress. It is important in the defense against infection. Vitamin-C possesses some anti-inflammatory activity and protects cells against oxidation damage to essential molecules. Its reductive capacity is important in iron metabolism and it is necessary for the incorporation of iron into ferritin and catalyses the reduction of ferric iron to the ferrous form. Vitamin-C increases iron absorption. The primary role of Vitamin-E is the prevention of oxidation of polyunsaturated fatty acids. Vitamin-E reacts with free radicals which are the cause of oxidative damage to cell membranes without the formation of another free radical in the process.

Dosage & Administration

The adult dose is one tablet daily or as prescribed by the physician.

Contraindication

Although human body converts Beta carotene to Vitamin-A only when required, yet excessive doses of Vitamin-A should be avoided in pregnancy because of potential teratogenic effects. Patients with hyperoxaluria. A pregnant woman taking more than 5gm Ascorbic Acid (Vitamin-C) daily may suffer foetal abortion. Higher doses of Vitamin-C have been reported to cause failure of conception. In case of Vitamin-E, there is no absolute contraindication.

Precaution

The administration of excessive amount of Vitamin-A over long period casn lead to toxicity, known as hypervitaminosis. This is characterized by fatigue, irritability, anorexia and loss of weight, vomiting and other gastrointestinal disturbances, low grade fever, hepatosplenomegaly, subcutaneous, swelling, and pain in bones and joints. Since the body converts carotene to retinol only in amounts as required, so there is no possibility of accumulation of Vitamin-A (Retinol) in the body. Patients who this preparation. Vitamin-C should be given with care to patients with hyperoxaluria. In patients taking oral anticoagulants or oestrogens, Vitamin-E should be given carefully because it has been found to antagonize the effects of Vitamin-K, leading to an increase in blood clotting time in these patients.

Pregnancy and Lactation

Vitamin-A should be avoided in pregnancy because of potential teratogenic effects. Patients with hyperoxaluria. A pregnant woman taking more than 5gm Ascorbic Acid (Vitamin-C) daily may suffer foetal abortion. Higher doses of Vitamin-C have been reported to cause failure of conception. In case of Vitamin-E, there is no absolute contraindication.

Side Effect

Loose stools may occasionally occur during treatment with Beta carotene and the skin may assume a slightly yellow discoloration. The toxic effect of vitamin A (after conversation of Beta carotene to it), which are encountered are normally reversible and an irreversible toxic effect is effectively unknown. Chronic over dosage can lead to peeling and redness of the skin, disturbed hair growth, loss of appetite and sickness. Vitamin-Casually well tolerated. Large doses are reported to cause diarrhea and other gastro-intestinal disturbances. It has also been stated that large doses may result in hyperoxaluria and the formation of renal calciumoxalate calculi and it should therefore be given with care to patients with hyperoaluria. Vitamin-E is usually well tolerated. Large doses may cause diarrhea, abdominal pain and other gastro-intestinal disturbances and have also been reported to cause fatigue and weakness.

Drug Interaction

There is no potentially hazardous drug interactions with retinol (after conversion of Beta Carotene to it). Both cadmium and copper decreases retinol plasma levels. Amoung antibiotics, neomycin and bleomycin reduce the absorption of retinol, Vitamin-C is in compatible in solution with aminophylline, leomycin, erythromycin, lactobionate, nafcillin, nitrofurantoin sodium, conjugated oestrogen, sodium bicarbonate, sulphafurazole diethanolamine, chloramphenicol sodium succinate, chlorothiazide sodium and hydrocortisone sodium succinate. It increase the apparent half-life of paracetamol and enhances iron absorption from the gastro-intestinal tract. No potentially useful druginteraction with Vitamin-E has been described. However, high doses of Vitamin-E can impair intestinal absorption of Vitamin A & K.

Storage

Keep in a cool dry place and protect from light.

Pack Size

Bottle containing 20 Tablets.

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